Harisiadis L, Miller R C, Harisiadis S, Hall E J
Br J Radiol. 1980 May;53(629):479-82. doi: 10.1259/0007-1285-53-629-479.
The potential of hyperthermia for producing oncogenic transformation in vitro was assessed using C3H/10T 1/2 mouse embryo cells. Temperatures in the range of 40 degrees to 45 degrees C caused no transformations, whether or not the heat treatment was associated with significant cell killing. In addition modest hyperthermia appreciably reduced the transformation frequencies associated with X-ray doses. The findings suggest an additional benefit in combining ionizing radiations with hyperthermia.
利用C3H/10T 1/2小鼠胚胎细胞评估了热疗在体外诱导致癌转化的潜力。40摄氏度至45摄氏度范围内的温度均未引起转化，无论热处理是否伴随着显著的细胞杀伤。此外，适度热疗明显降低了与X射线剂量相关的转化频率。这些发现表明，将电离辐射与热疗相结合还有额外的益处。
