Dattani J T, Exton-Smith A N, Stephen J M
Hum Nutr Clin Nutr. 1984 Mar;38(2):131-7.
Vitamin D status was assessed in 929 men and women aged 65 years and over during a nutrition survey lasting 56 weeks. Concentrations of 25-hydroxyvitamin D (25-OHD) measured in plasma samples showed a seasonal variation, being significantly higher in summer than in winter, and correlated with exposure to sunlight as measured by a 'sunshine score'. Regression analysis showed that 25-OHD concentrations fell with advancing age in both men and women and in summer and winter and approached the same value (about 10 ng/ml) at about the age of 95. This fall has implications in the occurrence of osteomalacia among the elderly and the increasing incidence with age of fractures of the femoral neck.
在一项为期56周的营养调查中,对929名65岁及以上的男性和女性的维生素D状况进行了评估。血浆样本中测得的25-羟基维生素D(25-OHD)浓度呈现季节性变化,夏季显著高于冬季,并且与通过“阳光评分”衡量的阳光照射量相关。回归分析表明,男性和女性在夏季和冬季的25-OHD浓度均随年龄增长而下降,在95岁左右接近相同水平(约10 ng/ml)。这种下降对老年人骨软化症的发生以及股骨颈骨折随年龄增长而增加的发病率具有影响。