16元环氧烯酮大环内酯类抗生素的深度氧化。II. 溶解金属还原法进行化学深度氧化
Deepoxidation of 16-membered epoxyenone macrolide antibiotics. II. Chemical deepoxidation by dissolving metal reduction.
作者信息
Mutoh Y, Shimauchi Y, Fukagawa Y, Ishikura T, Lein J
出版信息
J Antibiot (Tokyo). 1984 Feb;37(2):127-9. doi: 10.7164/antibiotics.37.127.
PMID:6706848
Abstract
16-Membered epoxyenone macrolide antibiotics were reductively deepoxidized with dissolving metals such as zinc. Angolamycin and rosamicin which have a methyl substituent at C-12 in the epoxyenone structure were deepoxidized, but not isomerized further to the geometric isomers P2 and P3.
摘要
16元环氧烯酮大环内酯类抗生素可通过锌等溶解金属进行还原深度氧化。在环氧烯酮结构中C-12位有甲基取代基的安哥拉霉素和罗沙米星被深度氧化，但未进一步异构化为几何异构体P2和P3。
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