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杂交大鼠中的血小板贮存池病。由与假定祖先(褐家鼠)杂交产生的F1淡褐色带帽大鼠。

Platelet storage pool disease in hybrid rats. F1 fawn-hooded rats derived from crosses with their putative ancestors (Rattus norvegicus).

作者信息

Tobach E, DeSantis J L, Zucker M B

出版信息

J Hered. 1984 Jan-Feb;75(1):15-8. doi: 10.1093/oxfordjournals.jhered.a109855.

DOI:10.1093/oxfordjournals.jhered.a109855
PMID:6707440
Abstract

Fawn-hooded rats have a hemorrhagic disorder known as platelet storage pool deficiency. Parent stocks of Fawn-hooded, Long-Evans, and Wistar (DAB) rats and the progeny of their reciprocal crosses were studied for coat color and percentage 14C-serotonin uptake and secretion by blood platelets. Progeny of Fawn-hooded and Wistar reciprocal crosses were dark- or light-hooded, whereas all reciprocal crosses with the Long-Evans stock were dark-hooded. The light or fawn hood was significantly associated with the reduced serotonin uptake and secretion characteristic of storage pool efficiency.

摘要

鹿毛色大鼠有一种出血性疾病,称为血小板储存池缺陷。对鹿毛色、长 Evans 和 Wistar(DAB)大鼠的亲本品系及其正反交后代进行了毛色以及血小板对 14C - 5 - 羟色胺摄取和分泌百分比的研究。鹿毛色大鼠与 Wistar 大鼠正反交的后代为深色或浅色毛,而与长 Evans 品系的所有正反交后代均为深色毛。浅色或鹿毛色与储存池效率降低所特有的 5 - 羟色胺摄取和分泌减少显著相关。

相似文献

1
Platelet storage pool disease in hybrid rats. F1 fawn-hooded rats derived from crosses with their putative ancestors (Rattus norvegicus).杂交大鼠中的血小板贮存池病。由与假定祖先(褐家鼠)杂交产生的F1淡褐色带帽大鼠。
J Hered. 1984 Jan-Feb;75(1):15-8. doi: 10.1093/oxfordjournals.jhered.a109855.
2
Genetics of the fawn-hooded rat strain. The coat color dilution and platelet storage pool deficiency are pleiotropic effects of the autosomal recessive red-eyed dilution gene.鹿毛色大鼠品系的遗传学。毛色稀释和血小板储存池缺陷是常染色体隐性红眼稀释基因的多效性效应。
J Hered. 1984 Sep-Oct;75(5):349-52. doi: 10.1093/oxfordjournals.jhered.a109954.
3
Regional analysis of 5-HT1A and 5-HT2 receptors in the fawn-hooded rat.对灰背大鼠中5-羟色胺1A和5-羟色胺2受体的区域分析。
Neuropharmacology. 1992 Nov;31(11):1095-9. doi: 10.1016/0028-3908(92)90004-9.
4
Serotonin uptake and imipramine binding in blood platelets and brain of Fawn-hooded and Sprague Dawley rats.褐家鼠和斯普拉格-道利大鼠血小板及大脑中5-羟色胺摄取与丙咪嗪结合情况
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Platelet membrane defects in fawn hooded bleeder rats.淡黄色带帽出血大鼠的血小板膜缺陷
Thromb Res. 1990 Feb 1;57(3):353-60. doi: 10.1016/0049-3848(90)90251-7.
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Decreased ATP, ADP and serotonin in young platelets of fawn-hooded rats with storage pool disease.患有储存池病的幼年褐家鼠血小板中三磷酸腺苷(ATP)、二磷酸腺苷(ADP)和血清素减少。
Thromb Diath Haemorrh. 1974 Dec 31;32(2-3):670-7.
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Ethanol intake and 3H-serotonin uptake I: A study in Fawn-Hooded rats.乙醇摄入与3H-血清素摄取I:对淡黄褐家鼠的一项研究。
Life Sci. 1991;48(20):1969-76. doi: 10.1016/0024-3205(91)90230-9.
8
Characterization of platelet abnormalities of Tester Moriyama (TM) rats with storage pool deficiency.对患有储存池缺陷的测试者森山(TM)大鼠血小板异常的特征描述。
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Further genetic characterization of the fawn-hooded (FH/Wjd) rat, an animal model of comorbid depression and alcoholism.对小鹿斑比毛色(FH/Wjd)大鼠这一抑郁症与酒精中毒共病动物模型的进一步基因特征分析。
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Effects of 5-hydroxytryptamine on the transintestinal electrical activity and cardiovascular function of fawn-hooded rats in-vivo.5-羟色胺对幼年有帽大鼠体内经肠电活动和心血管功能的影响。
J Pharm Pharmacol. 1999 Dec;51(12):1415-21. doi: 10.1211/0022357991777056.

引用本文的文献

1
The rat Ruby ( R) locus is Rab38: identical mutations in Fawn-hooded and Tester-Moriyama rats derived from an ancestral Long Evans rat sub-strain.大鼠Ruby(R)基因座是Rab38:源自祖先长Evans大鼠亚系的Fawn-hooded和Tester-Moriyama大鼠中的相同突变。
Mamm Genome. 2004 Apr;15(4):307-14. doi: 10.1007/s00335-004-2337-9.
2
Fawn-hooded rats show enhanced active behaviour in the forced swimming test, with no evidence for pituitary-adrenal axis hyperactivity.鹿毛色带帽大鼠在强迫游泳试验中表现出增强的主动行为,且没有垂体-肾上腺轴功能亢进的证据。
Psychopharmacology (Berl). 1996 May;125(1):74-8. doi: 10.1007/BF02247395.
3
Platelets of the Wistar Furth rat have reduced levels of alpha-granule proteins. An animal model resembling gray platelet syndrome.
Wistar Furth大鼠的血小板α-颗粒蛋白水平降低。一种类似灰色血小板综合征的动物模型。
J Clin Invest. 1991 Jun;87(6):1985-91. doi: 10.1172/JCI115226.
4
Genetic and environmental influences on reactive and spontaneous locomotor activities in rats.遗传和环境对大鼠反应性及自发性运动活动的影响。
Experientia. 1991 Oct 15;47(10):998-1008. doi: 10.1007/BF01923335.