Faden A I, Jacobs T P, Smith M T
J Neurosurg. 1984 Apr;60(4):796-9. doi: 10.3171/jns.1984.60.4.0796.
The potent, centrally active, calcium channel antagonist, nimodipine, was utilized in a highly predictive "spinal stroke" model in order to investigate the potential pathophysiological effects of calcium flux in spinal injury, as well as to evaluate the potential therapeutic role of the newly developed dihydropyridine derivatives in ischemic central nervous system injury. Nimodipine, administered before or after ischemia, at doses shown to be effective in improving cerebral blood flow and in dilating central blood vessels, failed to improve either the histopathological changes or the functional deficit caused by temporary aortic occlusion in the unanesthetized rabbit.
强效的、具有中枢活性的钙通道拮抗剂尼莫地平，被用于一个高度预测性的“脊髓卒中”模型，以研究钙内流在脊髓损伤中的潜在病理生理作用，以及评估新开发的二氢吡啶衍生物在缺血性中枢神经系统损伤中的潜在治疗作用。在缺血前或缺血后给予尼莫地平，其剂量已显示对改善脑血流和扩张中枢血管有效，但未能改善未麻醉兔因暂时性主动脉阻断引起的组织病理学变化或功能缺陷。
