Danielisova V, Chavko M
Department of Neurochemistry, Slovak Academy of Sciences, Kosice.
Neurochem Res. 1994 Dec;19(12):1503-7. doi: 10.1007/BF00968997.
The effect of the calcium channel blocker (KB-2796) on metabolic and functional recovery in rabbit spinal cord after 20, 30, and 40 min ischemia and 4 days of recovery was investigated. The drug was given intraperitoneally in three different doses, 10, 20, or 50 mg/kg pre- or post-ischemia of 20, 30, or 40 min duration. Both higher doses 20 and 30 mg/kg completely recovered energy state and significantly improved neurological functions in the spinal cord following 20 and 30 min ischemia. Partial protection was observed even after 40 min ischemia. The protective effect of KB-2796 exceeds the effect of calcium blockers previously used in experimental spinal cord ischemia.
研究了钙通道阻滞剂（KB - 2796）对兔脊髓在缺血20、30和40分钟及恢复4天后代谢和功能恢复的影响。该药物以三种不同剂量腹腔注射，在持续20、30或40分钟的缺血前后给予，剂量分别为10、20或50mg/kg。较高剂量20mg/kg和30mg/kg在20分钟和30分钟缺血后均能完全恢复能量状态，并显著改善脊髓神经功能。即使在缺血40分钟后也观察到部分保护作用。KB - 2796的保护作用超过了先前用于实验性脊髓缺血的钙通道阻滞剂的作用。
