Stuckey E, Berry C L
J Pathol. 1984 Mar;142(3):175-80. doi: 10.1002/path.1711420305.
BALB/c and CBA/h mice were used to investigate the teratogenic effects of sporadic high doses of ethanol. Two consecutive days between days 8 and 11 of organogenesis were chosen on which to administer 0.5 ml of 20 percent ethanol by gavage. An additional group was similarly dosed for four consecutive days starting on the eighth day. All the mice were killed on day 18 of gestation and evidence of growth retardation and malformation in the offspring was sought by skeletal and soft tissue screening. The basic pharmacokinetics of ethanol intake were also investigated. The most marked effects of ethanol were an increase in resorptions, skeletal growth retardation and skeletal variants, however all appeared to be strain specific. The results confirm that ethanol is embryotoxic and suggest that animal models are appropriate for studying aspects of growth retardation.
采用BALB/c和CBA/h小鼠研究偶发性高剂量乙醇的致畸作用。在器官形成的第8至11天之间选择连续两天，通过灌胃给予0.5毫升20%的乙醇。另一组从第8天开始连续4天给予同样剂量。所有小鼠在妊娠第18天处死，通过骨骼和软组织检查寻找后代生长迟缓及畸形的证据。同时也研究了乙醇摄入的基本药代动力学。乙醇最显著的作用是吸收增加、骨骼生长迟缓和骨骼变异，然而所有这些似乎都具有品系特异性。结果证实乙醇具有胚胎毒性，并表明动物模型适合用于研究生长迟缓的相关方面。
