Chernoff G F
Teratology. 1980 Aug;22(1):71-5. doi: 10.1002/tera.1420220110.
CBA, C3H, and C57 female mice maintained on a diet of 20 percent ethanol-derived calories prior to and throughout gestation were mated in a diallele cross. Prenatal death, malformations, and fetal weights were directly related to maternal blood alcohol levels, indicating a maternal effect. Fetal abnormalities and maternal blood alcohol levels varied with maternal strain (CBA > C3H > C57) and were inversely related to maternal alcohol dehydrogenase activity. Microsomal ethanol oxidizing systems induction was directly associated with increased fetal abnormalities, being greatest in CBA females. These results indicate that liability for the pattern of malformation observed in this syndrome is dependent on maternal blood alcohol levels, which are determined by the rate of maternal alcohol metabolism as well as the amount of maternal alcohol consumption.
在妊娠前及整个妊娠期维持由20%乙醇衍生热量组成饮食的CBA、C3H和C57雌性小鼠进行双等位基因杂交交配。产前死亡、畸形和胎儿体重与母体血液酒精水平直接相关，表明存在母体效应。胎儿异常和母体血液酒精水平因母体品系而异（CBA > C3H > C57），且与母体乙醇脱氢酶活性呈负相关。微粒体乙醇氧化系统的诱导与胎儿异常增加直接相关，在CBA雌性小鼠中最为明显。这些结果表明，该综合征中观察到的畸形模式的易感性取决于母体血液酒精水平，而母体血液酒精水平由母体酒精代谢速率以及母体酒精摄入量决定。
