通过单颗粒平均法对分子投影进行统计学显著性分析。

Statistical significance of molecule projections by single particle averaging.

作者信息

Haenicke W, Frank J, Zingsheim H P

出版信息

J Microsc. 1984 Feb;133(Pt 2):223-38. doi: 10.1111/j.1365-2818.1984.tb00488.x.

DOI:10.1111/j.1365-2818.1984.tb00488.x

Abstract

A statistical test based on a multiple comparison of Friedman's rank sums has been developed to determine the statistical significance of molecule projections obtained by non-crystallographic averaging techniques. The test, applied to electron microscope images of the acetylcholine receptor molecule, confirms the significance and quoted resolution of averages by Zingsheim et al. (1980, 1982a, b).

摘要

一种基于弗里德曼秩和多重比较的统计检验方法已被开发出来，用于确定通过非晶体学平均技术获得的分子投影的统计显著性。该检验方法应用于乙酰胆碱受体分子的电子显微镜图像，证实了津斯海姆等人（1980年、1982年a、b）所报道的平均值的显著性和分辨率。