Sullivan D A, Richardson G S, MacLaughlin D T, Wira C R
J Steroid Biochem. 1984 Jan;20(1):509-13. doi: 10.1016/0022-4731(84)90263-2.
To determine whether variations in the level of secretory component (SC) occur during the menstrual cycle, we compared the amounts of SC in human uterine secretions during the proliferative, secretory, and menstrual phases. Uterine washes were obtained from women (ages: 18-49) with histologically normal endometria by lavage with Gravlee jet wash device using isotonic glycine. SC was measured by a radioimmunoassay which recognizes primarily free SC. Levels of uterine luminal SC, when expressed as the percentage of total wash protein, were highest during the secretory phase, significantly reduced during the proliferative phase and lowest during menstruation. The mean protein concentration in uterine fluids did not vary significantly during the menstrual cycle. Total amounts of SC were also greatest during the secretory phase, averaging two times higher than SC levels in proliferative samples. These results demonstrate that fluctuations do occur in the SC content of human uterine secretions during the menstrual cycle and suggest that hormones play an important role in the secretory immune system of the human uterus.
为了确定分泌成分（SC）水平在月经周期中是否会发生变化，我们比较了人类子宫分泌物在增殖期、分泌期和月经期的SC含量。通过使用等渗甘氨酸的Gravlee喷射冲洗装置对子宫内膜组织学正常的女性（年龄：18 - 49岁）进行灌洗来获取子宫冲洗液。通过主要识别游离SC的放射免疫测定法来测量SC。当以总冲洗蛋白的百分比表示时，子宫腔SC水平在分泌期最高，在增殖期显著降低，在月经期最低。月经周期中子宫液中的平均蛋白浓度没有显著变化。SC的总量在分泌期也最大，平均比增殖期样本中的SC水平高两倍。这些结果表明，人类子宫分泌物中的SC含量在月经周期中确实会发生波动，提示激素在人类子宫的分泌免疫系统中起重要作用。
