Bacci M, Cavaliere A, Amorosi A
Oncology. 1984;41(2):106-8. doi: 10.1159/000225802.
3 mg/day procarbazine hydrochlorate, in a total dose of 300 mg, provoked tumours or raised their number in a variety of rat organs and tissues. 70.8% males and 92.5% females bore tumors against 16.6 and 33% of the controls. It is suggested that the lack of a specific target organ is due to the metabolic conversion of procarbazine to alkylating agents in the liver. The chemical structure, distribution of these agents within the organism and the different organ-specific enzyme activation and inhibition systems are probably responsible for the variable organotropism.
每天3毫克盐酸丙卡巴肼，总剂量达300毫克，可在多种大鼠器官和组织中诱发肿瘤或增加肿瘤数量。雄性大鼠中有70.8%、雌性大鼠中有92.5%出现肿瘤，而对照组的这一比例分别为16.6%和33%。有人认为缺乏特定靶器官是由于丙卡巴肼在肝脏中代谢转化为烷基化剂所致。这些药剂的化学结构、在生物体内的分布以及不同器官特异性的酶激活和抑制系统可能是导致器官嗜性差异的原因。
