Zbinden G, Maier P
Cancer Lett. 1983 Dec;21(2):155-61. doi: 10.1016/0304-3835(83)90202-1.
Rats carrying a 2-day-old subcutaneous air pouch were treated with single doses of procarbazine. Local fibrosarcomas developed in the pouch after oral, intraperitoneal and local administration of 300 mg/kg, but no tumours were induced if the drug was injected into unstimulated subcutaneous tissue. Tumours only appeared in those animals in which growth of the granuloma tissue was stimulated with a dose of croton oil. The high dose of procarbazine (300 mg/kg) also induced an increase in total tumour incidence at other sites.
给携带2日龄皮下气袋的大鼠单次注射丙卡巴肼。口服、腹腔注射和局部注射300mg/kg丙卡巴肼后，气袋处出现局部纤维肉瘤，但将药物注射到未受刺激的皮下组织中则不会诱发肿瘤。肿瘤仅出现在那些用巴豆油刺激肉芽肿组织生长的动物中。高剂量丙卡巴肼（300mg/kg）也导致其他部位的肿瘤总发生率增加。
