Mustafa S J, Mansour M M
Proc Soc Exp Biol Med. 1984 May;176(1):22-6. doi: 10.3181/00379727-176-41836.
This study was undertaken in an attempt to further understand the relationship between adenosine and H+ ion. Using Langendorff hearts from male rabbits, the perfusion fluid pH was lowered from 7.4 to 7.1 and 6.8 with CO2. A 31 and 86% increase in coronary flow with a simultaneous increase in the release of adenosine by 61 and 128% was observed at pH 7.1 and 6.8, respectively. A direct relationship between adenosine release and coronary flow with a correlation coefficient of 0.99 was found at pH values of 7.4, 7.1, and 6.8. The degradation products of adenosine namely inosine and hypoxanthine were unchanged at 7.1 and 6.8 from 7.4. These data support a role for adenosine in the regulation of coronary flow and suggest a relationship between adenosine and H+ ion.
本研究旨在进一步了解腺苷与氢离子之间的关系。使用雄性兔的Langendorff心脏，通过二氧化碳将灌注液的pH值从7.4降至7.1和6.8。在pH值为7.1和6.8时，分别观察到冠状动脉血流量增加31%和86%，同时腺苷释放量分别增加61%和128%。在pH值为7.4、7.1和6.8时，发现腺苷释放与冠状动脉血流量之间存在直接关系，相关系数为0.99。腺苷的降解产物即肌苷和次黄嘌呤在pH值为7.1和6.8时与7.4时相比没有变化。这些数据支持腺苷在冠状动脉血流调节中的作用，并表明腺苷与氢离子之间存在关系。
