White B C, Haswell K L, Kassab C D, Harkins D, Crumbie P M
Pharmacol Biochem Behav. 1984 Mar;20(3):387-9. doi: 10.1016/0091-3057(84)90276-4.
Caffeine-amphetamine interactions were studied to determine whether attenuation of amphetamine-induced activity by caffeine pretreatment (30 mg/kg) is the result of increased or decreased sensitivity to amphetamine. Caffeine pretreatment attenuated amphetamine activity in the rats without producing a horizontal shift in the dose-response curve. Results support a reduction in sensitivity to amphetamine. A cross-tolerance design revealed an asymmetrical interaction between caffeine and amphetamine. Multiple caffeine treatments (30 mg/kg) produced tolerance and attenuation of subsequent amphetamine activity (1.5 mg/kg). Amphetamine did not produce tolerance or affect subsequent caffeine-induced activity.
对咖啡因 - 苯丙胺相互作用进行了研究，以确定咖啡因预处理（30毫克/千克）对苯丙胺诱导的活动的减弱作用是由于对苯丙胺的敏感性增加还是降低所致。咖啡因预处理减弱了大鼠体内苯丙胺的活动，且未使剂量反应曲线发生水平位移。结果支持对苯丙胺敏感性降低的观点。交叉耐受设计揭示了咖啡因和苯丙胺之间的不对称相互作用。多次给予咖啡因（30毫克/千克）会产生耐受性，并减弱随后苯丙胺（1.5毫克/千克）诱导的活动。苯丙胺不会产生耐受性，也不会影响随后咖啡因诱导的活动。
