Swerdlow N R, Vaccarino F J, Koob G F
Pharmacol Biochem Behav. 1985 Sep;23(3):499-501. doi: 10.1016/0091-3057(85)90028-0.
We investigated the effects of naloxone on the locomotor activating properties of heroin (0.25 mg/kg SC), d-amphetamine (0.25 mg/kg SC) and caffeine (7.5 mg/kg SC). Naloxone eliminated heroin-stimulated locomotion at doses approximately six times lower than those that blocked amphetamine-stimulated locomotion. Caffeine-induced locomotor activation was insensitive to naloxone at all doses tested. These results suggest that central opiate systems are differentially involved in the behavioral activation produced by heroin, amphetamine and caffeine.
我们研究了纳洛酮对海洛因（0.25毫克/千克，皮下注射）、右旋苯丙胺（0.25毫克/千克，皮下注射）和咖啡因（7.5毫克/千克，皮下注射）的运动激活特性的影响。纳洛酮消除海洛因刺激的运动所需剂量比阻断苯丙胺刺激的运动所需剂量低约六倍。在所有测试剂量下，咖啡因诱导的运动激活对纳洛酮不敏感。这些结果表明，中枢阿片系统以不同方式参与海洛因、苯丙胺和咖啡因产生的行为激活。
