Faro S, Pastorek J G, Plauché W C, Korndorffer F A, Aldridge K E
South Med J. 1984 Apr;77(4):455-7. doi: 10.1097/00007611-198404000-00011.
A short-term course of an intravenous cephalosporin (cefuroxime) was used as therapy in 24 cases of pyelonephritis due to susceptible organisms in 23 pregnant women. Clinical cure was achieved in 96% of patients, and there were no adverse reactions to the drug. Bacteriologic cure was documented in 52% of those clinical cures, whereas 26% were considered to have bacterial colonization. However, 50% of those patients with bacteriologic cure subsequently had bacteriuria or pyelonephritis caused by other organisms. We conclude that women who have pyelonephritis in pregnancy are at high risk for subsequent urinary tract disease, even if adequately treated for their index infection. Short-term parenteral antibiotic therapy, followed by long-term oral suppressive therapy, is probably the treatment of choice for pyelonephritis complicating pregnancy.
对23名孕妇中因敏感菌引起肾盂肾炎的24例患者采用短期静脉注射头孢菌素（头孢呋辛）进行治疗。96%的患者实现了临床治愈，且未出现药物不良反应。临床治愈患者中有52%记录为细菌学治愈，而26%被认为存在细菌定植。然而，细菌学治愈的患者中有50%随后又出现了由其他细菌引起的菌尿或肾盂肾炎。我们得出结论，孕期患肾盂肾炎的女性即使对其初次感染进行了充分治疗，后续发生泌尿系统疾病的风险依然很高。短期肠外抗生素治疗，随后长期口服抑制性治疗，可能是妊娠合并肾盂肾炎的首选治疗方法。
