Bélanger L F
J Nutr. 1978 Aug;108(8):1315-21. doi: 10.1093/jn/108.8.1315.
Five groups consisting of 72 young male Sprague-Dawley rats were submitted to dietary Zn deprivation (1 ppm versus 50 ppm for controls) for periods of 1 to 6 weeks with ad libitum or pair feeding. After 1 week of Zn deficiency, growth was almost arrested, the oesophageal epithelium became hyperplastic. After 3 weeks, the mast cell population of the bone marrow increased rapidly in ad libitum fed and also in pair-fed rats. Between 3 and 5 weeks, the thickness of the proximal epiphyseal plate of the tibia decreased by 33%. Contrary to Mg-deficient rats, Zn-deprived rats maintained their skin and thyroid mast cell populations after 5 weeks. The mast cell population of the metaphysis of the tibia increased from 1 to 5 weeks in both Zn-deficient and Zn-supplemented rats. In the Zn-deprived rats however, the mast cell population became increasingly higher than in the Zn-supplemented, from 1 to 5 weeks. In the pair-fed group, the mast cell population of the marrow was also significantly higher after 3 weeks. The special response of the bone marrow cells to Zn-depletion points to this tissue as a renewal site. Zinc may also be a maturation factor for mast cells.
将五组每组72只雄性斯普拉格-道利幼鼠，置于锌缺乏饮食环境（实验组为1 ppm，对照组为50 ppm），持续1至6周，自由采食或配对喂养。锌缺乏1周后，生长几乎停滞，食管上皮增生。3周后，自由采食组和配对喂养组大鼠骨髓中的肥大细胞数量迅速增加。3至5周期间，胫骨近端骨骺板厚度下降了33%。与缺镁大鼠不同，缺锌大鼠在5周后皮肤和甲状腺中的肥大细胞数量保持不变。缺锌和补锌大鼠胫骨干骺端的肥大细胞数量在1至5周内均增加。然而，在缺锌大鼠中，1至5周内肥大细胞数量比补锌大鼠越来越高。在配对喂养组中，3周后骨髓中的肥大细胞数量也显著增加。骨髓细胞对锌缺乏的特殊反应表明该组织是一个细胞更新部位。锌也可能是肥大细胞的成熟因子。
