Green O C, Winter R J, Kawahara F S, Phillips L S, Lewy P R, Hart R L, Pachman L M
J Pediatr. 1978 Aug;93(2):299-303. doi: 10.1016/s0022-3476(78)80529-0.
Plasma prednisolone levels have been measured hourly in children receiving a single dose of oral prednisone. Peak prednisolone levels occurred one to two hours after ingestion; half-life studies gave a mean value of 132 minutes in most children. Some children had marked variability in absorption and metabolism of prednisone. Somatomedin activity and cell-mediated immunity were inhibited by plasma prednisolone values which were achieved by single doses of prednisone of 0.5 mg/kg or higher. Monitoring prednisolone levels may be of value in identifying those children who accumulate excessively high levels on moderate dosage regimens.
已对接受单剂量口服泼尼松的儿童每小时测量血浆泼尼松龙水平。泼尼松龙峰值水平在摄入后1至2小时出现；半衰期研究得出大多数儿童的平均值为132分钟。一些儿童在泼尼松的吸收和代谢方面存在明显差异。单剂量0.5mg/kg或更高剂量的泼尼松所达到的血浆泼尼松龙值可抑制生长介素活性和细胞介导的免疫。监测泼尼松龙水平对于识别那些在中等剂量方案下积累过高水平的儿童可能有价值。
