Clyde W A, Hu P C
Ann Microbiol (Paris). 1984 Jan-Feb;135A(1):125-8. doi: 10.1016/s0769-2609(84)80068-x.
Research advances of recent years are permitting new understanding of M. pneumoniae disease pathogenesis, although our knowledge remains incomplete. Colonization of the respiratory tract mucosa, mediated by an attachment protein, leads to specialized cell injury and altered muco-ciliary clearance. Pulmonary cellular infiltrates and airway exudates are a mixture of both non-specific and specific host immune responsiveness to the mycoplasma. It is now possible to begin integration of the organism's molecular biology and the clinical manifestations of infection.
尽管我们的认识仍不完整，但近年来的研究进展使人们对肺炎支原体疾病的发病机制有了新的认识。由一种黏附蛋白介导的呼吸道黏膜定植会导致特殊的细胞损伤和黏液纤毛清除功能改变。肺细胞浸润和气道渗出物是宿主对支原体非特异性和特异性免疫反应的混合表现。现在已经有可能将该病原体的分子生物学与感染的临床表现结合起来。
