使用人类基因组探针证实17号染色体上的I型胶原蛋白基因是COL1A1（α1（I））。
Confirmation that the type I collagen gene on chromosome 17 is COL1A1 (alpha 1(I), using a human genomic probe.
作者信息
Solomon E, Hiorns L, Sheer D, Rowe D
出版信息
Ann Hum Genet. 1984 Jan;48(1):39-42. doi: 10.1111/j.1469-1809.1984.tb00831.x.
Abstract
A cloned 15 kb genomic fragment from the human alpha 1(I) collagen gene (COL1A1) has been used as a probe on restriction digests of DNA from human-mouse somatic cell hybrids. Positive results on hybrids containing chromosome 17 as their only karyotypically visible human material confirm the assignment of this gene to chromosome 17. Hybrids which contain fragments of chromosome 17 are used to confirm the localization to 17q21-qter.
摘要
来自人类α1（I）胶原蛋白基因（COL1A1）的一个克隆的15 kb基因组片段已被用作探针，用于检测人-鼠体细胞杂种DNA的限制性酶切片段。对仅含有17号染色体作为其唯一核型可见人类物质的杂种的阳性结果，证实了该基因定位于17号染色体。含有17号染色体片段的杂种用于确认该基因定位于17q21 - qter。
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