Rausch R, Fedio P, Ary C M, Engel J, Crandall P H
Ann Neurol. 1984 Jan;15(1):31-5. doi: 10.1002/ana.410150106.
Recovery rates of selected behaviors following intracarotid sodium amobarbital injection were examined in 17 patients with unilateral focal temporal lobe epilepsy. Left hemisphere injections resulted in more prolonged disruption of naming (p less than 0.00001), reading (p less than 0.0001), matching-to-sample behaviors (p less than 0.05), and short-term recognition memory for pictures (p less than 0.0001) and words (p less than 0.0003) than did right hemisphere injections. In addition, recovery of behaviors was prolonged if the injection was administered to the hemisphere contralateral to that with the primary seizure focus (p less than 0.005). A trend toward a similar pattern was seen in the postinjection electroencephalogram with the maximum slowing found in the injected hemisphere prolonged if the epileptic focus was in the contralateral hemisphere (p = 0.06). These findings suggest a negative effect of an epileptic lesion on the contralateral hemisphere.
对17例单侧局灶性颞叶癫痫患者进行了颈动脉内注射戊巴比妥钠后特定行为的恢复率检查。与右侧半球注射相比，左侧半球注射导致命名（p<0.00001）、阅读（p<0.0001）、匹配样本行为（p<0.05）以及对图片（p<0.0001）和单词（p<0.0003）的短期识别记忆的破坏持续时间更长。此外，如果注射是在与主要癫痫病灶相对的半球进行，则行为恢复时间会延长（p<0.005）。在注射后的脑电图中也观察到类似的趋势，即如果癫痫病灶位于对侧半球，则注射半球的最大慢波持续时间会延长（p = 0.06）。这些发现表明癫痫病灶对对侧半球有负面影响。
