Hearn S, Ott M G, Kolesar R C, Cook R R
Arch Environ Health. 1984 Jan-Feb;39(1):49-55. doi: 10.1080/00039896.1984.10545833.
Concern about the carcinogenic potential of 1,2-dibromo-3-chloropropane(DBCP) has arisen recently, focusing on six organ sites: stomach, liver, kidney, lung, testes, and skin. To examine the mortality experience of persons potentially exposed, a cohort of 550 employees involved in production and formulation from 1957 to 1976 was defined. A total of 35 deaths was observed through 1979 (39.2 expected). No statistically significant excess was observed for any cause of death. No cancer deaths were noted for five of the hypothesized sites. For the lung cancer category, five deaths were observed (2.7 expected, P greater than .135), two of which occurred in a subgroup directly exposed for at least 1 yr (0.5 expected, P greater than .077). Aside from arsenicals exposure, potential confounding resulting from smoking or multiple chemical exposures could not be evaluated.
最近人们对1,2 - 二溴 - 3 - 氯丙烷（DBCP）的致癌潜力产生了关注，重点关注六个器官部位：胃、肝脏、肾脏、肺、睾丸和皮肤。为了研究可能接触该物质的人员的死亡情况，确定了一个由1957年至1976年期间参与生产和配方工作的550名员工组成的队列。到1979年共观察到35例死亡（预期为39.2例）。未观察到任何死因的统计学显著超额死亡。在五个假设部位未发现癌症死亡病例。对于肺癌类别，观察到5例死亡（预期为2.7例，P大于0.135），其中2例发生在直接接触至少1年的亚组中（预期为0.5例，P大于0.077）。除了砷暴露外，无法评估吸烟或多种化学物质暴露导致的潜在混杂因素。
