Wong O, Brocker W, Davis H V, Nagle G S
Br J Ind Med. 1984 Feb;41(1):15-24. doi: 10.1136/oem.41.1.15.
A historical prospective mortality study was conducted on 3579 white male workers employed between 1935 and 1976 with potential exposures to brominated compounds including 1,2-dibromo-3-chloropropane (DBCP), Tris (2,3-dibromopropyl) phosphate, polybrominated biphenyls (PBB), various organic and inorganic bromides, and DDT. The vital status as of 31 December 1976 was determined for 3384 (95%) of these workers: 2806 (79%) were still living and 578 (16%) had died. Death certificates were obtained for 541 deaths (94% of all deaths). The mortality experience of the entire cohort and several subcohorts was compared with that of United States white men adjusted for age and calendar time. The comparison statistic was the commonly used standardised mortality ratio (SMR). Historical industrial hygiene data were not available, and the workers were classified by their work areas or departments in order to estimate their potential exposures. Overall mortality for the entire cohort and several subgroups was significantly lower than expected. For the entire cohort, significant mortality deficits were observed in diseases of the circulatory system, non-malignant respiratory disease, and diseases of the digestive system. On the other hand, mortality from diabetes mellitus was significantly raised for the cohort. No significant overall or cause-specific mortality excess was detected among employees potentially exposed to either TRIS or DDT. A significant mortality excess due to diseases of the circulatory system was observed among workers potentially exposed to DBCP. Mortality from testicular cancer was significantly higher than expected among those potentially exposed to other organic bromides. The common potential exposure of those who had died of testicular cancer was methyl bromide. Owing to the lack of accurate historical exposure information and the fact that many workers were potentially exposed to a multitude of chemicals, it is difficult to draw definitive statements on the causations of the observed mortality excesses.
对1935年至1976年间受雇的3579名白人男性工人进行了一项历史性前瞻性死亡率研究，这些工人有可能接触溴化化合物，包括1,2 - 二溴 - 3 - 氯丙烷（DBCP）、磷酸三（2,3 - 二溴丙基）酯、多溴联苯（PBB）、各种有机和无机溴化物以及滴滴涕（DDT）。截至1976年12月31日，确定了其中3384名（95%）工人的生命状态：2806名（79%）仍在世，578名（16%）已死亡。获取了541例死亡（占所有死亡人数的94%）的死亡证明。将整个队列以及几个亚队列的死亡率与按年龄和日历时间调整后的美国白人男性死亡率进行了比较。比较统计量是常用的标准化死亡率（SMR）。没有可获取的历史工业卫生数据，为了估计工人的潜在接触情况，根据他们的工作区域或部门对其进行了分类。整个队列以及几个亚组的总体死亡率显著低于预期。对于整个队列，在循环系统疾病、非恶性呼吸系统疾病和消化系统疾病方面观察到显著的死亡率不足。另一方面，该队列中糖尿病死亡率显著升高。在可能接触TRIS或DDT的员工中，未检测到总体或特定病因的显著死亡率过高情况。在可能接触DBCP的工人中，观察到循环系统疾病导致的显著死亡率过高。在可能接触其他有机溴化物的人群中，睾丸癌死亡率显著高于预期。死于睾丸癌的人群的常见潜在接触物是甲基溴。由于缺乏准确的历史接触信息，并且许多工人可能接触多种化学物质，因此难以就观察到的死亡率过高的病因得出明确结论。
