类风湿因子及免疫复合物成分在早期关节炎中的滑膜合成
Synovial synthesis of rheumatoid factors and immune complex constituents in early arthritis.
作者信息
Jones V, Taylor P C, Jacoby R K, Wallington T B
出版信息
Ann Rheum Dis. 1984 Apr;43(2):235-9. doi: 10.1136/ard.43.2.235.
Abstract
Synovial synthesis of immune complex constituents and rheumatoid factors has been estimated in rheumatoid arthritis (RA) and in unclassifiable inflammatory arthritis (IA) and related to duration of symptoms. Within 6 months of onset of symptoms both RA and IA patients synthesised (or trapped) immune complexes locally. However, local synthesis of the rheumatoid factors was almost exclusive to RA patients and mainly in patients with symptoms of more than 6 months' duration. Thus all arthritis patients may respond immunologically to an initial trigger in the affected joint but only RA patients develop localised chronic autoimmunity later.
摘要
类风湿关节炎（RA）和无法分类的炎性关节炎（IA）患者的滑膜免疫复合物成分和类风湿因子的合成情况已被评估，并与症状持续时间相关。在症状出现的6个月内，RA和IA患者均在局部合成（或捕获）免疫复合物。然而，类风湿因子的局部合成几乎仅见于RA患者，且主要见于症状持续超过6个月的患者。因此，所有关节炎患者可能会对受影响关节的初始触发因素产生免疫反应，但只有RA患者随后会发展为局部慢性自身免疫。
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