播散性淋球菌感染患者滑膜液和血清中的免疫复合物：关节内局部免疫复合物形成的证据。
Immune complexes in synovial fluid and serum from patients with disseminated gonococcal infection: evidence for local immune complex formation within the joint.
作者信息
Shiel W C, Andrews B S, Friou G J, Barada F A, Scopelitis E, Martin D A
出版信息
Ann Rheum Dis. 1986 Oct;45(10):816-20. doi: 10.1136/ard.45.10.816.
Twenty one patients with acute arthritis associated with disseminated gonococcal infection (DGI) were studied. Synovial fluid (SF) from 14 and serum from 15 (matched in eight) were assayed for the presence of immune complexes (IC) by the Raji cell immunofluorescent assay (Raji IFA) and the 125I-Clq polyethylene glycol (PEG) binding assay. Higher levels and frequency of IC were detected in the SF by both IC assays and these were associated with a significant increase in complexes containing IgM over serum (p less than 0.02). Complexes containing IgG were found predominantly in serum and were infrequent in SF (p less than 0.003). These data suggest that the arthritis of DGI may result from primary immune complex formation within the synovial cavity after local antibody synthesis within the synovium in response to gonococcal seeding.
对21例与播散性淋球菌感染（DGI）相关的急性关节炎患者进行了研究。通过Raji细胞免疫荧光测定法（Raji IFA）和125I-Clq聚乙二醇（PEG）结合测定法，对14例患者的滑液（SF）和15例患者的血清（其中8例配对）进行了免疫复合物（IC）检测。两种IC检测方法均在SF中检测到更高水平和频率的IC，且这些IC与血清中含IgM的复合物显著增加相关（p<0.02）。含IgG的复合物主要存在于血清中，在SF中很少见（p<0.003）。这些数据表明，DGI的关节炎可能是由于滑膜内针对淋球菌接种的局部抗体合成后，滑膜腔内原发性免疫复合物形成所致。
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