Elson C J, Carter S D, Cottrell B J, Scott D G, Bacon P A, Wallington T B
Clin Exp Immunol. 1985 Feb;59(2):285-92.
The relationship between complexes containing rheumatoid factor and complexes activating complement was examined in synovial fluids and sera from patients with rheumatoid arthritis (RA). In each case this was performed by quantifying the amount of rheumatoid factor bound by solid phase Fab'2 anti-C3 and/or solid phase conglutinin. Both anti-C3 coated and conglutinin coated microtitre plates bound high levels of complexes containing rheumatoid factor from sera of RA patients with vasculitis. Unexpectedly, these complexes were detected in synovial fluids from only a minority of RA patients with synovitis. However, RA synovial fluids did contain other complexes as shown by the presence of complement consuming activity, C1q binding material and immunoglobulin attaching to conglutinin. It is considered that in RA synovial fluids the complexes containing RF and those activating complement are not necessarily the same whilst in vasculitic sera the complexes containing rheumatoid factor also activate complement.
在类风湿性关节炎（RA）患者的滑液和血清中，研究了含类风湿因子的复合物与激活补体的复合物之间的关系。在每种情况下，这都是通过定量固相Fab'2抗C3和/或固相胶固素结合的类风湿因子的量来进行的。抗C3包被的和胶固素包被的微量滴定板都能结合来自患有血管炎的RA患者血清中高水平的含类风湿因子的复合物。出乎意料的是，这些复合物仅在少数患有滑膜炎的RA患者的滑液中被检测到。然而，RA滑液确实含有其他复合物，如补体消耗活性、C1q结合物质和附着于胶固素的免疫球蛋白的存在所示。据认为，在RA滑液中，含RF的复合物和激活补体的复合物不一定相同，而在血管炎血清中，含类风湿因子的复合物也能激活补体。
