Agudelo C A, Turner R A, Panetti M, Pisko E
Arthritis Rheum. 1984 Apr;27(4):443-8. doi: 10.1002/art.1780270412.
The negative association between gout and rheumatoid arthritis is well accepted. The reason for this mutual exclusion is not clear; a protective immunosuppressive effect of hyperuricemia has been included among possible explanations. To test this hypothesis, we reviewed the charts of 160 rheumatoid arthritis patients on whom clinical information and followup for at least a year were available. We selected those patients with persistent hyperuricemia as defined by serum urate levels averaging above 7.5 mg% for at least 6 months. We found 12 patients fulfilling such criteria, and 11 of these were judged to have quiescent, minimally active, or inactive disease during hyperuricemic periods. In 2 patients, flares of the rheumatoid process coincided with normalization of serum urate levels. We propose that persistent hyperuricemia may protect against or decrease the expression of rheumatoid inflammation.
痛风与类风湿性关节炎之间的负相关关系已被广泛认可。这种相互排斥的原因尚不清楚；高尿酸血症的保护性免疫抑制作用已被列入可能的解释之中。为了验证这一假设，我们查阅了160例类风湿性关节炎患者的病历，这些患者均有临床资料且随访时间至少为一年。我们选择了那些血清尿酸水平平均高于7.5mg%至少6个月定义为持续性高尿酸血症的患者。我们发现有12名患者符合这些标准，其中11名在高尿酸血症期间被判定为病情静止、轻度活动或不活动。在2名患者中，类风湿病情的发作与血清尿酸水平的正常化同时出现。我们认为，持续性高尿酸血症可能预防或减少类风湿炎症的表现。
