Walker J M, Wilmshurst P T, Juul S M, Coltart D J
Br J Clin Pharmacol. 1984 Mar;17(3):301-7. doi: 10.1111/j.1365-2125.1984.tb02345.x.
An acute intravenous bolus of 10 mg ketanserin (a specific 5-HT antagonist) caused an abrupt fall in left ventricular systolic pressure of 17 +/- 9.2 mm Hg (P less than 0.025) in ten patients undergoing cardiac catheterisation for chest pains. A fall in pulmonary artery diastolic pressure of 2.1 +/- 0.74 mm Hg (P less than 0.02) was also observed. No changes in resting heart rate occurred and the response to pacing was largely unmodified by ketanserin, except for a reduction in pulmonary vascular resistance (3.70 +/- 1.27 units to 2.97 +/- 1.44 units, P less than 0.05), at the fastest rate (136 +/- 3 beats/min). At the highest pacing rate coronary sinus blood flow fell (83 +/- 12 ml 100 g-1 min-1 to 68 +/- 8 ml 100 g-1 min-1, P less than 0.05), as did myocardial oxygen consumption (18 +/- 2 ml-1 min to 14 +/- 1 ml min-1, P less than 0.05) after the drug. No changes in the parameters of left ventricular contractile function could be attributed to ketanserin, save for a modest increase in the ejection fraction (48 +/- 6% to 57 +/- 6%, P less than 0.05) in seven patients. There were no alterations in myocardial metabolism of lactate, pyruvate, hydroxybutyrate, glycerol nor free fatty acids after ketanserin. The findings are consistent with a peripheral site of action of this drug and its blood pressure lowering effect in the subjects suggest a non-specific hypotensive action rather than an anti-hypertensive effect.
对于因胸痛接受心导管插入术的10名患者，静脉快速推注10毫克酮色林（一种特异性5-羟色胺拮抗剂）后，左心室收缩压突然下降17±9.2毫米汞柱（P<0.025）。还观察到肺动脉舒张压下降2.1±0.74毫米汞柱（P<0.02）。静息心率无变化，除了在最快心率（136±3次/分钟）时肺血管阻力降低（从3.70±1.27单位降至2.97±1.44单位，P<0.05）外，酮色林对起搏反应的影响不大。在最高起搏频率时，冠状窦血流量下降（从83±12毫升100克-1分钟-1降至68±8毫升100克-1分钟-1，P<0.05），用药后心肌耗氧量也下降（从18±2毫升-1分钟降至14±1毫升分钟-1，P<0.05）。除了7名患者的射血分数略有增加（从48±6%增至57±6%，P<0.05）外，左心室收缩功能参数的变化不能归因于酮色林。酮色林用药后，心肌中乳酸、丙酮酸、羟丁酸、甘油和游离脂肪酸的代谢无变化。这些发现与该药物的外周作用部位一致，其在受试者中的降压作用表明是一种非特异性的降压作用，而非抗高血压作用。
