Marklund S L, Midander J, Westman G
Biochim Biophys Acta. 1984 Apr 24;798(3):302-5. doi: 10.1016/0304-4165(84)90102-8.
The effect of genetically determined glutathione deficiency on the fibroblast content of CuZn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase was investigated. No significant differences between glutathione-deficient and -proficient human fibroblasts were revealed. There was a large variation in the content of the investigated enzymes in fibroblasts grown and analysed on different occasions. Whereas the contents of CuZn superoxide dismutase, catalase and glutathione peroxidase did not deviate much from what has been found in other human cell-lines and tissues, the fibroblasts were found to contain exceptional amounts of Mn superoxide dismutase.
研究了基因决定的谷胱甘肽缺乏对铜锌超氧化物歧化酶、锰超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶在成纤维细胞中含量的影响。未发现谷胱甘肽缺乏型和谷胱甘肽充足型人成纤维细胞之间存在显著差异。在不同时间培养和分析的成纤维细胞中，所研究酶的含量存在很大差异。虽然铜锌超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的含量与在其他人类细胞系和组织中发现的情况相差不大，但发现这些成纤维细胞含有异常大量的锰超氧化物歧化酶。
