小鼠胰岛及其他组织中的铜锌超氧化物歧化酶、锰超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶
CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
作者信息
Grankvist K, Marklund S L, Täljedal I B
出版信息
Biochem J. 1981 Nov 1;199(2):393-8. doi: 10.1042/bj1990393.
Abstract
Exogenous superoxide dismutase, catalase and scavengers of the hydroxyl radical protect pancreatic-islet cells against the toxic actions of alloxan in vitro [Grankvist et al. (1979) Biochem. J. 182, 17--25]. To test whether the extraordinary sensitivity of islet cells to alloxan is due to a deficiency of endogenous enzymes protecting against oxygen-reduction products, we assayed CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in mouse islets and other tissues. To correct for any blood contamination, haemoglobin was also measured in the tissue samples. Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes. However, the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
摘要
外源性超氧化物歧化酶、过氧化氢酶和羟自由基清除剂可在体外保护胰岛细胞免受四氧嘧啶的毒性作用[格兰克维斯特等人（1979年）《生物化学杂志》182卷，17 - 25页]。为了检验胰岛细胞对四氧嘧啶的非凡敏感性是否是由于缺乏抵御氧还原产物的内源性酶，我们测定了小鼠胰岛及其他组织中的铜锌超氧化物歧化酶、锰超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶。为校正任何血液污染，还对组织样本中的血红蛋白进行了测定。发现胰岛属于保护酶活性相对较低的组织。然而，在这方面与其他组织的偏差可能不足以解释胰岛细胞对四氧嘧啶特别高的敏感性。
相似文献
1
CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.小鼠胰岛及其他组织中的铜锌超氧化物歧化酶、锰超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶
Biochem J. 1981 Nov 1;199(2):393-8. doi: 10.1042/bj1990393.
2
Normal CuZn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in Werner's syndrome.沃纳综合征中的正常铜锌超氧化物歧化酶、锰超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶。
J Gerontol. 1981 Jul;36(4):405-9. doi: 10.1093/geronj/36.4.405.
3
Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity.混合胰岛移植中的人胰岛可保护小鼠胰腺β细胞免受四氧嘧啶毒性的影响。
Pharmacol Toxicol. 1999 Dec;85(6):269-75. doi: 10.1111/j.1600-0773.1999.tb02021.x.
4
5
6
Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro.超氧化物歧化酶、过氧化氢酶、螯合剂和自由基清除剂对四氧嘧啶体外对分离胰岛毒性的影响。
Free Radic Biol Med. 1999 May;26(9-10):1300-4. doi: 10.1016/s0891-5849(98)00325-6.
7
Superoxide dismutase, catalase, and glutathione peroxidase activities in copper/zinc-superoxide dismutase transgenic mice.铜/锌超氧化物歧化酶转基因小鼠中超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性
J Neurochem. 1992 May;58(5):1760-7. doi: 10.1111/j.1471-4159.1992.tb10051.x.
8
Factor analysis of the activities of superoxide dismutase, catalase and glutathione peroxidase in normal tissues and neoplastic cell lines.正常组织和肿瘤细胞系中超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性的因子分析
Free Radic Res Commun. 1987;4(1):1-13. doi: 10.3109/10715768709088082.
9
Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro.超氧化物歧化酶、过氧化氢酶和羟自由基清除剂可在体外保护胰岛细胞免受四氧嘧啶的毒性作用。
Biochem J. 1979 Jul 15;182(1):17-25. doi: 10.1042/bj1820017.
10
Enhanced expression of glutathione peroxidase protects islet beta cells from hypoxia-reoxygenation.谷胱甘肽过氧化物酶表达增强可保护胰岛β细胞免受缺氧复氧损伤。
Xenotransplantation. 2004 Jan;11(1):53-9. doi: 10.1111/j.1399-3089.2004.00082.x.
引用本文的文献
1
Neutrophils in Type 1 Diabetes: Untangling the Intricate Web of Pathways and Hypothesis.1型糖尿病中的中性粒细胞：梳理复杂的信号通路网络与假说
Biomolecules. 2025 Mar 31;15(4):505. doi: 10.3390/biom15040505.
2
Distribution of glutathione peroxidase-1 immunoreactive cells in pancreatic islets from type 1 diabetic donors and non-diabetic donors with and without islet cell autoantibodies is variable and independent of disease.1型糖尿病供体以及有和没有胰岛细胞自身抗体的非糖尿病供体的胰岛中谷胱甘肽过氧化物酶-1免疫反应性细胞的分布是可变的，且与疾病无关。
Cell Tissue Res. 2025 Mar 10. doi: 10.1007/s00441-025-03955-5.
3
Perlecan: An Islet Basement Membrane Protein with Protective Anti-Inflammatory Characteristics.基底膜聚糖：一种具有保护性抗炎特性的胰岛基底膜蛋白。
Bioengineering (Basel). 2024 Aug 13;11(8):828. doi: 10.3390/bioengineering11080828.
4
Pancreatic Crosstalk in the Disease Setting: Understanding the Impact of Exocrine Disease on Endocrine Function.疾病状态下的胰腺相互作用：了解外分泌疾病对内分泌功能的影响。
Compr Physiol. 2024 Mar 29;14(2):5371-5387. doi: 10.1002/cphy.c230008.
5
Association of xanthine oxidoreductase inhibitor use with insulin secretory capacity in patients with type 2 diabetes.黄嘌呤氧化酶抑制剂的使用与 2 型糖尿病患者胰岛素分泌能力的关系。
J Diabetes Investig. 2024 Oct;15(10):1500-1509. doi: 10.1111/jdi.14279. Epub 2024 Jul 30.
6
Effects of selective serotonin reuptake inhibitors on endocrine system (Review).选择性5-羟色胺再摄取抑制剂对内分泌系统的影响（综述）
Biomed Rep. 2024 Jul 5;21(3):128. doi: 10.3892/br.2024.1816. eCollection 2024 Sep.
7
RISING STARS: Evidence for established and emerging forms of β-cell death.新星崛起：β细胞死亡的既定形式和新兴形式的证据。
J Endocrinol. 2024 Jul 4;262(2). doi: 10.1530/JOE-23-0378. Print 2024 Aug 1.
8
CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8 T cells in diabetic autoimmunity.胰岛巨噬细胞通过 CXCL16 依赖性清除氧化脂质促进糖尿病自身免疫中致病性 CD8 T 细胞的分化。
Immunity. 2024 Jul 9;57(7):1629-1647.e8. doi: 10.1016/j.immuni.2024.04.017. Epub 2024 May 15.
9
Pancreatic β-Cell Identity Change through the Lens of Single-Cell Omics Research.通过单细胞组学研究的视角看胰腺 β 细胞的身份变化。
Int J Mol Sci. 2024 Apr 26;25(9):4720. doi: 10.3390/ijms25094720.
10
Antioxidants for Early Treatment of Type 2 Diabetes in Rodents and Humans: Lost in Translation?抗氧化剂治疗 2 型糖尿病：在啮齿动物和人类中的翻译失落？
Diabetes. 2024 May 1;73(5):653-658. doi: 10.2337/db23-0901.
本文引用的文献
1
Dimethylurea: a radical scavenger that protects isolated pancreatic islets from the effects of alloxan and dihydroxyfumarate exposure.二甲基脲：一种自由基清除剂，可保护分离的胰岛免受四氧嘧啶和二羟基富马酸暴露的影响。
Life Sci. 1980 Apr 28;26(17):1405-9. doi: 10.1016/0024-3205(80)90043-0.
2
Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase, and a metal chelator.超氧化物歧化酶、过氧化氢酶和金属螯合剂对分离的胰岛中四氧嘧啶作用的抑制
Diabetes. 1980 Mar;29(3):213-6. doi: 10.2337/diab.29.3.213.
3
Determination of pancreatic islet mass by measurement of native protein fluorescence.通过测量天然蛋白质荧光来测定胰岛质量。
Anal Biochem. 1980 Jan 15;101(2):494-7. doi: 10.1016/0003-2697(80)90219-5.
4
Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.自由基与炎症：血浆中中性粒细胞趋化因子的超氧化物依赖性激活
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1159-63. doi: 10.1073/pnas.77.2.1159.
5
Induction of diabetes by cumulative environmental insults from viruses and chemicals.病毒和化学物质累积性环境损伤诱导糖尿病。
Nature. 1980 Nov 27;288(5789):383-5. doi: 10.1038/288383a0.
6
Reduction of linolenic acid hydroperoxide by a glutathione peroxidase.
Biochim Biophys Acta. 1969 Apr 29;176(3):463-70. doi: 10.1016/0005-2760(69)90213-6.
7
Effect of insulin in vivo on diaphragm and adipose tissue of obese mice.胰岛素在体内对肥胖小鼠膈肌和脂肪组织的作用。
Am J Physiol. 1969 Jan;216(1):98-105. doi: 10.1152/ajplegacy.1969.216.1.98.
8
Measurements of insulin activities in pancreas and serum of mice with spontaneous ("Obese" and "New Zealand Obese") and induced (Goldthioglucose) obesity and hyperglycemia, with considerations on the pathogenesis of the spontaneous syndrome.
Diabetologia. 1967 Apr;3(2):230-7. doi: 10.1007/BF01222200.
9
Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).超氧化物歧化酶。红细胞铜蛋白（血铜蛋白）的酶功能。
J Biol Chem. 1969 Nov 25;244(22):6049-55.
10
Quantitative studies on isolated pancreatic islets of mammals. Activity and heterogeneity of lactate dehydrogenase in obese-hyporglycemic mice.哺乳动物分离胰岛的定量研究。肥胖低血糖小鼠中乳酸脱氢酶的活性与异质性。
Endocrinology. 1967 Jul;81(1):125-31. doi: 10.1210/endo-81-1-125.
Zotero 插件