Jamieson L, Stribling D, Rothwell N J, Stock M J
Can J Physiol Pharmacol. 1984 Jan;62(1):136-41. doi: 10.1139/y84-022.
Metabolic rate and tissue blood flow were measured by indirect calorimetry and the radioactive microsphere technique, respectively, in anaesthetized pigs aged 10, 17, and 28 days during infusions of saline or noradrenaline. Noradrenaline produced a rise in oxygen consumption in all pigs but the magnitude of the response declined with age in Large White pigs (percent increase: 10 days old, 29.5 +/- 3.3; 17 days old, 15.3 +/- 3.2; 28 days old, 5.4 +/- 0.17) and was less in 10-day-old Minipigs (9.1 +/- 5.1). Regional blood flow per gram of tissue was similar for pigs of all ages and noradrenaline produced increases in flow to heart and skin, and small reductions in blood flow to skeletal muscle. Noradrenaline increased average blood flow to adipose tissue (four sites) by 21-fold in 10-day-old Large White pigs, but had less effect in 10-day-old Minipigs (9.5-fold) and in older Large White pigs (9-fold), where the effect on metabolic rate was diminished. It is calculated that adipose tissue could be responsible for the increase in metabolic rate during infusion of noradrenaline. Macroscopically there are no gross differences between various adipose tissue depots in the pig but those which showed the greatest response to noradrenaline correspond to areas where brown adipocytes have previously been identified by electron microscopy.
在10日龄、17日龄和28日龄的麻醉猪输注生理盐水或去甲肾上腺素期间，分别采用间接测热法和放射性微球技术测量代谢率和组织血流量。去甲肾上腺素使所有猪的耗氧量增加，但大白猪的反应幅度随年龄下降（增加百分比：10日龄，29.5±3.3；17日龄，15.3±3.2；28日龄，5.4±0.17），10日龄小型猪的反应较小（9.1±5.1）。所有年龄猪的每克组织区域血流量相似，去甲肾上腺素使心脏和皮肤的血流量增加，骨骼肌的血流量略有减少。去甲肾上腺素使10日龄大白猪脂肪组织（四个部位）的平均血流量增加21倍，但对10日龄小型猪（9.5倍）和年龄较大的大白猪（9倍）的影响较小，在这些猪中对代谢率的影响减弱。据计算，脂肪组织可能是输注去甲肾上腺素期间代谢率增加的原因。宏观上，猪的各种脂肪组织库之间没有明显差异，但对去甲肾上腺素反应最大的部位对应于先前通过电子显微镜鉴定出棕色脂肪细胞的区域。
