P物质作用于大鼠腮腺切片所介导的钾离子短暂释放。
A transient release of potassium mediated by the action of substance P on rat parotid slices.
作者信息
Friedman Z Y, Selinger Z
出版信息
J Physiol. 1978 May;278:461-9. doi: 10.1113/jphysiol.1978.sp012317.
Abstract
Substance P (a peptide of eleven amino acids) caused a Ca-dependent release of K+ from rat parotid slices. The response to substance P differed from the alpha-adrenergic and the cholinergic responses in that it was transient, of smaller extent, and was not inhibited by phentolamine and atropine. Substance P caused little, if any, amylase secretion. Successive additions of the peptide to the slice system maintained the effect of C+ release indicating that the transient response to a single addition of the peptide was due to inactivation of substance P and not due to a decline in the response of the tissue.
摘要
P物质（一种由11个氨基酸组成的肽）可使大鼠腮腺切片依赖钙离子释放钾离子。P物质引起的反应与α-肾上腺素能反应和胆碱能反应不同，其反应是短暂的，程度较小，且不受酚妥拉明和阿托品的抑制。P物质几乎不引起淀粉酶分泌（如果有分泌的话也极少）。向切片系统中连续添加该肽可维持钾离子释放的效应，这表明对单次添加该肽的短暂反应是由于P物质失活，而非组织反应性下降所致。
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