文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

J Physiol. 1977 Jun;268(1):139-49. doi: 10.1113/jphysiol.1977.sp011851.

Carbachol, phenylephrine and substance P were each capable of producing a transient release of K (86 Rb) from rat parotid slices in the absence of extracellular Ca. 2. Each of the agonists was also capable of producing "cross-receptor inactivation"; that is, if a transient response was elicited by any one of the agonists then no transient response could be obtained by either of the other two. 3. Removal of carbachol from muscarinic receptors with atropine did not reverse the cross-receptor inactivation of the substance P response unless Ca was added with substance P or unless Ca was present when atropine was added. 4. It is concluded that the K release response in the parotid gland is mediated by receptor-controlled Ca influx sites. These influx sites also bind Ca at a location inaccessible to EGTA and release the bound Ca upon receptor activation. 5. It is also conlcuded that all three receptors (muscarinic, alpha-adrenergic, and peptide) appear to regulate the same Ca influx sites.

在无细胞外钙的情况下，卡巴胆碱、去氧肾上腺素和P物质均可使大鼠腮腺切片短暂释放钾（⁸⁶Rb）。2. 每种激动剂还能产生“交叉受体失活”；也就是说，如果任何一种激动剂引发了短暂反应，那么另外两种激动剂都无法引发短暂反应。3. 用阿托品从毒蕈碱受体上除去卡巴胆碱，除非在加入P物质时同时加入钙，或者在加入阿托品时细胞外存在钙，否则不会逆转P物质反应的交叉受体失活。4. 得出的结论是，腮腺中的钾释放反应是由受体控制的钙内流位点介导的。这些内流位点还在乙二醇双（2-氨基乙基醚）四乙酸（EGTA）无法到达的位置结合钙，并在受体激活时释放结合的钙。5. 还得出结论，所有三种受体（毒蕈碱受体、α-肾上腺素能受体和肽受体）似乎都调节相同的钙内流位点。

J Physiol. 1977 Jun;268(1):139-49. doi: 10.1113/jphysiol.1977.sp011851.

Carbachol, phenylephrine and substance P were each capable of producing a transient release of K (86 Rb) from rat parotid slices in the absence of extracellular Ca. 2. Each of the agonists was also capable of producing "cross-receptor inactivation"; that is, if a transient response was elicited by any one of the agonists then no transient response could be obtained by either of the other two. 3. Removal of carbachol from muscarinic receptors with atropine did not reverse the cross-receptor inactivation of the substance P response unless Ca was added with substance P or unless Ca was present when atropine was added. 4. It is concluded that the K release response in the parotid gland is mediated by receptor-controlled Ca influx sites. These influx sites also bind Ca at a location inaccessible to EGTA and release the bound Ca upon receptor activation. 5. It is also conlcuded that all three receptors (muscarinic, alpha-adrenergic, and peptide) appear to regulate the same Ca influx sites.

在无细胞外钙的情况下，卡巴胆碱、去氧肾上腺素和P物质均可使大鼠腮腺切片短暂释放钾（⁸⁶Rb）。2. 每种激动剂还能产生“交叉受体失活”；也就是说，如果任何一种激动剂引发了短暂反应，那么另外两种激动剂都无法引发短暂反应。3. 用阿托品从毒蕈碱受体上除去卡巴胆碱，除非在加入P物质时同时加入钙，或者在加入阿托品时细胞外存在钙，否则不会逆转P物质反应的交叉受体失活。4. 得出的结论是，腮腺中的钾释放反应是由受体控制的钙内流位点介导的。这些内流位点还在乙二醇双（2-氨基乙基醚）四乙酸（EGTA）无法到达的位置结合钙，并在受体激活时释放结合的钙。5. 还得出结论，所有三种受体（毒蕈碱受体、α-肾上腺素能受体和肽受体）似乎都调节相同的钙内流位点。