Rudich L, Butcher F R
Biochim Biophys Acta. 1976 Oct 22;444(3):704-11. doi: 10.1016/0304-4165(76)90317-2.
The undecapeptides, substance P and eledoisin, caused a rapid, concentration-dependent increase in K+ efflux and amylase release from parotid tissue slices. The effects were not blocked by beta-adrenergic, alpha-adrenergic, or cholinergic antagonists. Incubation buffer calcium was required for stimulation of K efflux and amylase release. The action of the undecapepides was independent of any effects on parotid cyclic AMP or cyclic GMP levels. Since the actions of the undecapeptides were Ca2+ dependent and no effects on cyclic nucleotide levels were discerned it was concluded that Ca2+ plays a primary role in agonist regulation of K+ efflux from the parotid.
十一肽P物质和eledoisin可使腮腺组织切片的钾离子外流和淀粉酶释放迅速增加，且呈浓度依赖性。这些作用不受β-肾上腺素能、α-肾上腺素能或胆碱能拮抗剂的阻断。刺激钾离子外流和淀粉酶释放需要孵育缓冲液中的钙离子。十一肽的作用与对腮腺环磷酸腺苷或环磷酸鸟苷水平的任何影响无关。由于十一肽的作用依赖于钙离子，且未发现对环核苷酸水平有影响，因此得出结论，钙离子在激动剂调节腮腺钾离子外流中起主要作用。
