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Should levodopa therapy be started early or late?

作者信息

Muenter M D

出版信息

Can J Neurol Sci. 1984 Feb;11(1 Suppl):195-9. doi: 10.1017/s0317167100046400.

DOI:10.1017/s0317167100046400
PMID:6713317
Abstract

Clinical and experimental evidence suggests that, in Parkinson's disease, the late-occurring fluctuations in response to levodopa therapy are due to progression of the disease rather than to the therapy. Therefore, treatment with carbidopa/levodopa should be started early, because postponement does not provide patients with added benefits but deprives them of the most satisfying period of the therapeutic response.

摘要

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引用本文的文献

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Levodopa in Parkinson's disease: neurotoxicity issue laid to rest?帕金森病中的左旋多巴：神经毒性问题已得到解决？
Drug Saf. 1999 Nov;21(5):339-52. doi: 10.2165/00002018-199921050-00001.
2
Age influences magnitude but not duration of response to levodopa.年龄影响对左旋多巴反应的程度，但不影响反应的持续时间。
J Neurol Neurosurg Psychiatry. 1993 Jan;56(1):65-8. doi: 10.1136/jnnp.56.1.65.
3
Parkinson's disease in 1984: an update.1984年的帕金森病：最新情况
Can Med Assoc J. 1984 Nov 1;131(9):1031-7.
4
Levodopa-induced dyskinesia: clinical observations.左旋多巴诱发的运动障碍：临床观察
J Neurol. 1985;232(1):29-31. doi: 10.1007/BF00314037.
5
Parkinson's disease.
CMAJ. 1989 Mar 1;140(5):507-14.