Kalimi G H, Sirsat S M
Cancer Lett. 1984 Apr;22(3):343-50. doi: 10.1016/0304-3835(84)90173-3.
Gap junctions are known to mediate cell to cell coupling. This study shows that the potent tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), drastically affects the presence of gap junctions between mouse interfollicular epidermal (IFE) cells. In a time course ultrastructural study after a single application of 1 microgram of TPA the gap junctions between the IFE basal cells begin to decrease by 10 h post-exposure, are totally absent between 18 h and 30 h, and start reappearing at 30 h after TPA application. The potent hyperplasiogen , but very weak tumor promoter, mezerein, produces comparable hyperplasia and wide intercellular spaces but the population of gap junctions remains unchanged.
已知间隙连接介导细胞间偶联。本研究表明，强效肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）会极大地影响小鼠毛囊间表皮（IFE）细胞之间间隙连接的存在情况。在单次应用1微克TPA后的时间进程超微结构研究中，IFE基底细胞之间的间隙连接在暴露后10小时开始减少，在18小时至30小时之间完全消失，并在TPA应用后30小时开始重新出现。强效增生剂但非常弱的肿瘤启动子芫花酯素会产生类似的增生和宽大的细胞间隙，但间隙连接的数量保持不变。
