Khan S N, Rahman M A, Samad A
Clin Chem. 1984 May;30(5):644-8.
We examined sera from 159 patients with ischemic heart disease and hypertension and from 50 apparently healthy control subjects for content of trace elements, cholesterol, triglyceride, and enzymes. Concentrations of copper, cobalt, cholesterol, and triglyceride were increased in all patients, but calcium was decreased in patients with hypertension, acute myocardial ischemia, and acute myocardial infarction. Also accompanying acute myocardial infarction were decreased concentrations of zinc and iron but increases in nickel, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. Magnesium concentration was lower in patients with acute myocardial ischemia. In acute myocardial infarction, the concentrations of copper, zinc, and iron were higher after 21-30 h (as compared with the values at 0-10 h), by which time concentrations of calcium, magnesium, cobalt, and alanine aminotransferase had decreased. The variation in concentration of trace elements in serum from cases of ischemic heart disease and hypertension corresponds to the severity of the disorder.
我们检测了159例缺血性心脏病和高血压患者以及50例明显健康的对照者血清中的微量元素、胆固醇、甘油三酯和酶的含量。所有患者的铜、钴、胆固醇和甘油三酯浓度均升高，但高血压、急性心肌缺血和急性心肌梗死患者的钙含量降低。急性心肌梗死还伴有锌和铁浓度降低，但镍、天冬氨酸转氨酶、丙氨酸转氨酶和乳酸脱氢酶升高。急性心肌缺血患者的镁浓度较低。在急性心肌梗死中，21 - 30小时后铜、锌和铁的浓度升高（与0 - 10小时的值相比），此时钙、镁、钴和丙氨酸转氨酶的浓度已降低。缺血性心脏病和高血压患者血清中微量元素浓度的变化与疾病的严重程度相符。
