Fraser J R, Laurent T C, Engström-Laurent A, Laurent U G
Clin Exp Pharmacol Physiol. 1984 Jan-Feb;11(1):17-25. doi: 10.1111/j.1440-1681.1984.tb00235.x.
The removal of hyaluronic acid (HA) from the blood-stream was studied in four normal human subjects after injection of high molecular weight preparations labelled with 3H in the acetyl position. The plasma half-life of the injected material ranged between 2.5 and 5.5 min. The daily turnover of HA in the circulation was estimated to be at least 150 mg. Its elimination was predominantly extrarenal, the upper molecular weight limit for renal excretion being 25 000. Evidence for rapid degradation was provided by the identification of 3H2O in urine. Calculations from the specific activity of urinary 3H2O indicated that approximately 55% of the acetyl content of the injected HA was completely oxidized within 3 h, and 85% within the first day. It is concluded that hyaluronic acid in the amounts currently used for therapeutic purposes should not accumulate significantly in the circulation.
在四名正常人类受试者中，研究了注射在乙酰基位置用³H标记的高分子量制剂后，透明质酸（HA）从血流中的清除情况。注射物质的血浆半衰期在2.5至5.5分钟之间。循环中HA的每日周转率估计至少为150毫克。其消除主要是肾外的，肾排泄的分子量上限为25000。尿液中³H₂O的鉴定提供了快速降解的证据。根据尿液中³H₂O的比活性计算表明，注射的HA中约55%的乙酰含量在3小时内完全氧化，第一天内氧化85%。得出的结论是，目前用于治疗目的的透明质酸量在循环中不应显著积累。
