Sorsa M, Falck K, Heinonen T, Vainio H, Norppa H, Rimpelä M
Environ Res. 1984 Apr;33(2):312-21. doi: 10.1016/0013-9351(84)90029-x.
A volunteer study was carried out on groups smoking low-tar (5.4 mg/cig.) and medium-tar (16.3 mg/cig.) cigarettes and on non-smokers. The number of cigarettes smoked was recorded daily throughout a 51-day study period, and the effects of smoking were measured in the beginning and after 3-week terms of smoking medium-tar or low-tar cigarettes. The parameters measured were blood carboxyhemoglobin concentration, thioethers excreted into the urine, mutagenic activity in the urine, and the frequency of sister-chromatid exchanges in blood lymphocytes. For all four parameters, the differences between the smokers and the non-smokers were significant. However, within the study design no differences could be detected between low-tar or medium-tar cigarette smoking in the biological-monitoring tests used.
对吸低焦油（5.4毫克/支）和中焦油（16.3毫克/支）香烟的人群以及不吸烟者进行了一项志愿者研究。在为期51天的研究期间，每天记录吸烟数量，并在开始吸中焦油或低焦油香烟3周后测量吸烟的影响。所测量的参数包括血液中碳氧血红蛋白浓度、尿液中排出的硫醚、尿液中的诱变活性以及血液淋巴细胞中姐妹染色单体交换的频率。对于所有这四个参数，吸烟者和不吸烟者之间的差异是显著的。然而，在所使用的生物监测测试中，在该研究设计内未检测到吸低焦油或中焦油香烟之间的差异。
