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人类c-myc基因座的核苷酸序列：第一个外显子内有启发性的开放阅读框。

Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon.

作者信息

Gazin C, Dupont de Dinechin S, Hampe A, Masson J M, Martin P, Stehelin D, Galibert F

出版信息

EMBO J. 1984 Feb;3(2):383-7. doi: 10.1002/j.1460-2075.1984.tb01816.x.

DOI:10.1002/j.1460-2075.1984.tb01816.x
PMID:6714223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC557354/
Abstract

The nucleotide sequence of a HindIII-EcoRI DNA fragment, 8 kbp long, of a lambda recombinant containing the whole human c-myc gene has been deduced by the method of Maxam and Gilbert. This fragment encodes the complex c-myc locus and the sequence provides information relative to the 2.7 kb long c-myc transcript. It appears that although exons 2 and 3 would code for a 48-K protein homologous to the myc domain of the viral p110 gag-myc protein, the first exon, which has a large open reading frame ending with a stop codon just upstream from the donor splice site, could code on its own for a 20-K protein. Speculations about the role of that putative protein on the regulation of the expression of exons 2 and 3 are made.

摘要

采用马克萨姆和吉尔伯特法推导了含整个人类c-myc基因的λ重组体中一段8千碱基对长的HindIII-EcoRI DNA片段的核苷酸序列。该片段编码复杂的c-myc基因座，其序列提供了与2.7千碱基对长的c-myc转录本相关的信息。虽然外显子2和3编码的48-K蛋白与病毒p110 gag-myc蛋白的myc结构域同源，但第一个外显子有一个大的开放阅读框，在供体剪接位点上游刚好以一个终止密码子结束，它自身可能编码一个20-K蛋白。文中对该假定蛋白在调节外显子2和3表达中的作用进行了推测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af0/557354/9f66399f0f5a/emboj00306-0127-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af0/557354/9f66399f0f5a/emboj00306-0127-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af0/557354/9f66399f0f5a/emboj00306-0127-a.jpg

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