Dimant J, Ginzler E M, Diamond H S, Schlesinger M, Marino C T, Weiner M, Kaplan D
J Rheumatol. 1978 Summer;5(2):136-41.
A computer analysis of 234 patients with SLE followed for an average of 31 months revealed 22 patients with aseptic necrosis of bone (AN) (9%), with projected frequency approaching 30% at 10-15 years of follow-up. Most patients developed between four and seven years after diagnosis of SLE. When compared to all other patients with SLE and no AN or to three computer-selected groups matched by age of SLE diagnosis, duration of disease, or cumulative corticosteroid dose, AN did not correlate with any of the preliminary ARA criteria, total number of criteria fulfilled, renal disease, skin vasculitis, or disease activity. Although all patients received corticosteroid therapy prior to development of AN, no correlation was found with duration, peak dose, or cumulative dose of corticosteroid therapy.
对234例系统性红斑狼疮（SLE）患者进行平均31个月的随访，计算机分析显示22例患者发生骨无菌性坏死（AN）（9%），预计随访10 - 15年时发生率接近30%。大多数患者在SLE诊断后4至7年发病。与所有其他无AN的SLE患者或与按SLE诊断年龄、病程或累积皮质类固醇剂量计算机选择匹配的三组患者相比，AN与任何初步的美国风湿病学会（ARA）标准、符合标准的总数、肾脏疾病、皮肤血管炎或疾病活动度均无相关性。虽然所有患者在发生AN之前均接受了皮质类固醇治疗，但未发现与皮质类固醇治疗的持续时间、峰值剂量或累积剂量相关。
