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[手部非典型关节炎:胶原病 - 第1部分]

[Atypical arthritis of the hands : Collagenosis-part 1].

作者信息

Bollow Matthias

机构信息

Ruhr-Universität Bochum, Bochum, Deutschland.

Klinik für diagnostische und interventionelle Radiologie, Augusta-Kranken-Anstalt Bochum, Bergstraße 26, 44791, Bochum, Deutschland.

出版信息

Radiologe. 2021 May;61(5):458-469. doi: 10.1007/s00117-021-00840-4. Epub 2021 Mar 29.

Abstract

BACKGROUND

Systemic lupus erythematosus (SLE) is a gynecotropic autoimmune vasculitis with manifestations in various organ systems including the skin, internal organs, and joints.

OBJECTIVE

Presentation of the atypical arthritis patterns of the hands in SLE as the most common autoimmunologic rheumatologic disease from the group of collagenoses in the context of clinical and serological findings and considering the classification criteria of the American College of Rheumatology compared to rheumatoid arthritis (RA) and psoriatic arthritis (PsA).

MATERIALS AND METHODS

Narrative review based on the current literature on the subject from a radiological and rheumatological point of view.

RESULTS

In 80-90% of all SLE cases, hand joint manifestations can be detected, mostly in the form of non-erosive oligo- or polyarthralgias with the picture of so-called luxation arthropathies and with the pattern of a so-called Jaccoud's or Lupus' syndrome, which are accompanied by "carpal instability" in 15% of cases. In association with an antiphospholipid antibody syndrome, ischemic osteonecrosis may occur in 5-50% of SLE, predominantly in weight-bearing areas of the skeleton, and less frequently in the carpal bones or metacarpal heads. The rare rhupus syndrome comprises patients with overlap of RA and SLE features.

CONCLUSIONS

Due to the heterogeneity of the symptoms and the often individually very different courses, the diagnosis of SLE can be difficult. Since new drug therapy concepts have significantly increased the 5‑year survival rates of SLE from 0% in the 1950s to 70-90% in recent decades, a timely and definite diagnosis is necessary, to which radiologists can also contribute by correctly classifying the image morphological SLE arthritis patterns in the hands.

摘要

背景

系统性红斑狼疮(SLE)是一种亲妇科的自身免疫性血管炎,可累及包括皮肤、内脏和关节在内的多个器官系统。

目的

结合临床和血清学检查结果,介绍SLE中手部非典型关节炎模式,SLE是胶原病组中最常见的自身免疫性风湿性疾病,并将其与类风湿关节炎(RA)和银屑病关节炎(PsA)相比较,同时考虑美国风湿病学会的分类标准。

材料与方法

从放射学和风湿病学角度,基于关于该主题的当前文献进行叙述性综述。

结果

在所有SLE病例中,80% - 90%可检测到手关节表现,大多表现为非侵蚀性少关节或多关节痛,呈现所谓的脱位性关节病图像以及所谓的雅库病或狼疮综合征模式,其中15%的病例伴有“腕关节不稳”。与抗磷脂抗体综合征相关时,5% - 50%的SLE患者可能发生缺血性骨坏死,主要发生在骨骼的负重部位,腕骨或掌骨头较少见。罕见的rhupus综合征包括具有RA和SLE特征重叠的患者。

结论

由于症状的异质性以及病程通常个体差异很大,SLE的诊断可能困难。由于新的药物治疗理念显著提高了SLE的5年生存率,从20世纪50年代的0%提高到近几十年的70% - 90%,因此需要及时明确诊断,放射科医生通过正确分类手部SLE关节炎的图像形态模式也能对此做出贡献。

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