Gneushev E T, Ponomarenko E L, Kurapov A P, Kukes V G
Farmakol Toksikol. 1984 Mar-Apr;47(2):52-4.
Ten patients without marked abnormalities on the part of the liver and kidneys were examined for the pharmacokinetics of a new Soviet antiarrhythmic drug etacizin. The drug was injected intravenously at a rate of 0.5-0.8 mg/kg bw. The blood required for determining drug concentrations was taken 1, 2, 3 and 4 hours after drug jet injection. It was demonstrated that the drug half-life was on the average 164 +/- 24.7 min, exceeding 2 times the half-life of etmozine, a drug of the same series applied to the treatment of some forms of heart rhythm abnormalities.
对10名肝脏和肾脏无明显异常的患者进行了一种新型苏联抗心律失常药物乙卡嗪的药代动力学研究。以0.5 - 0.8毫克/千克体重的速率静脉注射该药物。在静脉推注药物后1、2、3和4小时采集用于测定药物浓度的血液。结果表明，该药物的半衰期平均为164±24.7分钟，超过了用于治疗某些心律失常形式的同系列药物乙吗噻嗪半衰期的2倍。
