Wilkins W E, Ridley M G, Pozniak A L
Gut. 1984 May;25(5):478-80. doi: 10.1136/gut.25.5.478.
The medication history of patients presenting with benign oesophageal stricture is compared with an age and sex matched control population selected from the community. Fifty five out of 151 consecutive admissions to a dysphagia clinic were found to have benign oesophageal stricture. Twenty six out of 53 (49%) had been prescribed non-steroidal anti-inflammatory drugs in the year preceding their clinic appointment. Ten patients (19%) had been prescribed other drugs implicated in oesophageal disease over the same period. In the control population, 20 out of 165 (12%) had been prescribed non-steroidal anti-inflammatory drugs, and 31 out of 165 had been prescribed 'other' drugs in the preceding year. The difference between numbers on non-steroidal anti-inflammatory drugs in the patient and control groups was highly significant (X2 = 23.87, p less than 0.1%). This study has shown an association between the prescribing of non-steroidal anti-inflammatory drugs and benign stricture of the oesophagus.
将出现良性食管狭窄患者的用药史与从社区中选取的年龄和性别匹配的对照人群进行比较。在一家吞咽困难诊所连续收治的151例患者中，有55例被发现患有良性食管狭窄。在诊所就诊前一年，53例患者中有26例（49%）曾被开具非甾体类抗炎药。同期有10例患者（19%）曾被开具其他与食管疾病有关的药物。在对照人群中，165例中有20例（12%）在前一年被开具非甾体类抗炎药，165例中有31例被开具“其他”药物。患者组和对照组非甾体类抗炎药使用人数的差异具有高度显著性（X2 = 23.87，p小于0.1%）。这项研究表明非甾体类抗炎药的处方与食管良性狭窄之间存在关联。
