Shallcross T M, Wyatt J I, Rathbone B J, Heatley R V
Department of Medicine, St James's Hospital, Leeds.
Br J Rheumatol. 1990 Aug;29(4):288-90. doi: 10.1093/rheumatology/29.4.288.
The frequency of oesophageal ulceration in 55 patients undergoing endoscopy for dyspeptic symptoms and who had recently used NSAIDs was studied, and compared with 86 patients seen in the same clinic who had not recently used these drugs. Oesophageal ulceration was significantly more common in those who had used NSAIDs (P = 0.012), and also showed a highly significant association with the presence of a hiatus hernia (P less than 0.001). No association was found between the presence of gastric Helicobacter pylori and either oesophageal ulceration or histological oesophagitis. Patients receiving NSAIDs, especially those with a hiatus hernia, are at risk of oesophageal ulceration and presumably subsequent stricture formation. This should be borne in mind when prescribing these agents.
对55例因消化不良症状接受内镜检查且近期使用过非甾体抗炎药（NSAIDs）的患者的食管溃疡发生率进行了研究，并与同一诊所86例近期未使用这些药物的患者进行了比较。使用NSAIDs的患者食管溃疡明显更常见（P = 0.012），并且与食管裂孔疝的存在也有高度显著相关性（P < 0.001）。未发现胃幽门螺杆菌的存在与食管溃疡或组织学食管炎之间存在关联。接受NSAIDs治疗的患者，尤其是患有食管裂孔疝的患者，有发生食管溃疡以及可能随后形成狭窄的风险。在开具这些药物处方时应牢记这一点。
