人类精子中的染色体异常：四名健康男性的比较。
Chromosomal abnormalities in human sperm: comparisons among four healthy men.
作者信息
Brandriff B, Gordon L, Ashworth L, Watchmaker G, Carrano A, Wyrobek A
出版信息
Hum Genet. 1984;66(2-3):193-201. doi: 10.1007/BF00286600.
We have used the human-sperm/hamster-egg system to compare the frequencies of structural and numerical chromosomal aberrations in 909 sperm karyotypes from four normal healthy men. The frequency of structural aberrations was 1.3, 4.8, 9.0, and 10.4% respectively in the four donors. Certain specific breakpoints were seen twice or even three times in three of the donors. The incidence of aneuploidy was 1.3, 1.4, 1.4, and 1.9%. In three donors the frequencies of structural aberrations were significantly higher in sperm than in lymphocytes from the same man. X-to-Y ratios did not differ significantly from the expected 50:50.
我们利用人精子/仓鼠卵系统，比较了4名正常健康男性的909个精子核型中结构和数目染色体畸变的频率。4名供体的结构畸变频率分别为1.3%、4.8%、9.0%和10.4%。在3名供体中，某些特定的断点出现了两次甚至三次。非整倍体的发生率分别为1.3%、1.4%、1.4%和1.9%。在3名供体中，精子中结构畸变的频率显著高于同一男性淋巴细胞中的频率。X与Y的比例与预期的50:50没有显著差异。
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