凝血因子VII和X在13q34区域的定位。因子VII通过8号染色体表达。
Regional mapping of clotting factors VII and X to 13q34. Expression of factor VII through chromosome 8.
作者信息
de Grouchy J, Dautzenberg M D, Turleau C, Beguin S, Chavin-Colin F
出版信息
Hum Genet. 1984;66(2-3):230-3. doi: 10.1007/BF00286607.
PMID:6714981
Abstract
Blood clotting factors were investigated in a patient with trisomy 8 mosaicism, a patient with an r(13), and a patient with distal trisomy 13q. Results are compatible with the assignment of the structural genes of factors VII and X to 13q34 and the existence of a regulatory mechanism associated with chromosome 8 controlling the expression of factor VII alone.
摘要
对一名8号染色体嵌合体患者、一名13号环状染色体（r(13)）患者和一名13号染色体长臂末端三体（13q末端三体）患者的凝血因子进行了研究。结果表明，凝血因子VII和X的结构基因定位于13q34，并且存在一种与8号染色体相关的调控机制，该机制仅控制凝血因子VII的表达。
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