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High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine.

作者信息

Cundy K C, Crooks P A

出版信息

J Chromatogr. 1984 Mar 9;306:291-301. doi: 10.1016/s0378-4347(00)80891-9.

DOI:10.1016/s0378-4347(00)80891-9
PMID:6715467
Abstract

An analytical method has been developed, using cation-exchange high-performance liquid chromatography, for the analysis of N-methylated metabolites of nicotine. This method has been used to detect and quantitate seven potential in vivo urinary metabolites of [2'-14C]-nicotine, including four methylated nicotine derivatives, in the guinea pig.

摘要

相似文献

1
High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine.
J Chromatogr. 1984 Mar 9;306:291-301. doi: 10.1016/s0378-4347(00)80891-9.
2
Evidence of stereospecificity in the in vivo methylation of [14C](+/-)-nicotine in the guinea pig.豚鼠体内[14C](+/-)-尼古丁甲基化过程中立体特异性的证据。
Drug Metab Dispos. 1984 Nov-Dec;12(6):755-9.
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Stereospecific in vivo N-methylation of nicotine in the guinea pig.
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Biotransformation of primary nicotine metabolites. II. Metabolism of [3H]-S-(-)-cotinine in the guinea pig: determination of in vivo urinary metabolites by high-performance liquid-radiochromatography.
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Species variation and stereoselectivity in the metabolism of nicotine enantiomers.尼古丁对映体代谢中的物种差异和立体选择性。
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Biotransformation of primary nicotine metabolites. I. In vivo metabolism of R-(+)-[14C-NCH3]N-methylnicotinium ion in the guinea pig.主要尼古丁代谢物的生物转化。I. 豚鼠体内R-(+)-[14C-NCH3]N-甲基烟碱离子的代谢
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Species differences in the metabolic C- and N-oxidation , and N-methylation of [14C]pyridine in vivo.[¹⁴C]吡啶在体内代谢的碳和氮氧化及氮甲基化的种属差异。
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High-performance liquid chromatographic determination of nicotine and its urinary metabolites via their 1,3-diethyl-2-thiobarbituric acid derivatives.通过尼古丁及其尿液代谢物的1,3 - 二乙基 - 2 - 硫代巴比妥酸衍生物进行高效液相色谱法测定。
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Enantioselective metabolism during continuous administration of S-(-)- and R-(+)-nicotine isomers to guinea-pigs.在向豚鼠连续给药S-(-)-和R-(+)-尼古丁异构体期间的对映选择性代谢。
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[Development of analytical method for determination nicotine metabolites in urine].[尿液中尼古丁代谢物测定分析方法的建立]
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