Person J R, Longcope C
J Am Acad Dermatol. 1984 Feb;10(2 Pt 1):235-8. doi: 10.1016/s0190-9622(84)70029-6.
Becker's nevus is an uncommon, unilateral, hyperpigmented, hairy cutaneous hamartoma which usually begins in adolescence. Its clinical features and its occurrence mainly in male individuals suggest that androgen stimulation may play a role in its pathogenesis. Androgen receptor assays were performed in a 16-year-old patient with a Becker's nevus. The patient coincidentally had acanthosis nigricans. Lesional tissue showed an androgen receptor level of 634.1 fm/mg protein. A specimen from the contralateral left pectoral area showed no dectectable androgen receptor activity (less than 2.0 fm/mg protein). These results suggest that exquisite androgen sensitivity and stimulation may explain the clinical manifestations of Becker's nevus.
贝克尔痣是一种罕见的、单侧性、色素沉着、多毛的皮肤错构瘤，通常始于青春期。其临床特征以及主要发生于男性个体表明，雄激素刺激可能在其发病机制中起作用。对一名患有贝克尔痣的16岁患者进行了雄激素受体检测。该患者同时患有黑棘皮病。病变组织显示雄激素受体水平为634.1飞摩尔/毫克蛋白。来自对侧左胸区域的标本未检测到雄激素受体活性（低于2.0飞摩尔/毫克蛋白）。这些结果表明，对雄激素的高度敏感性和刺激可能解释了贝克尔痣的临床表现。
