Tagami H, Ginoza M, Imaizumi S, Urano-Suehisa S
J Am Acad Dermatol. 1984 Apr;10(4):615-9. doi: 10.1016/s0190-9622(84)80266-2.
Four female patients with chromoblastomycosis were completely cured by prolonged topical application of tolerable heat from pocket warmers. The lesions involuted after 2, 3, and 6 months, respectively, in three patients who faithfully followed our strict treatment schedule, in contrast to the fourth patient who performed the topical heat therapy in an irregular manner at home over a 12-month period. In vitro studies showed that the mature colonies of Fonsecaea pedrosoi, isolated from three of the patients, withstood persistent heating at 42.5 degrees C for more than 1 month. This suggested that heat killing of the causative organisms is unlikely to have been the sole reason for the effectiveness of this simple therapeutic modality.
四名着色芽生菌病女性患者通过长期局部应用暖手宝产生的可耐受热量而完全治愈。三名严格遵循我们严格治疗方案的患者，其皮损分别在2个月、3个月和6个月后消退，与之形成对比的是，第四名患者在家中以不规律的方式进行局部热疗，持续了12个月。体外研究表明，从三名患者身上分离出的裴氏瓶霉成熟菌落能够耐受42.5摄氏度的持续加热超过1个月。这表明，热杀死致病微生物不太可能是这种简单治疗方式有效的唯一原因。
